Adult thrombocytopenia

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Study record managers: refer to the Data Element Definitions if submitting registration or results information. The study includes a 4-week screening period, a month romiplostim treatment period, and a romiplostim dose-tapering period. Participants who dose reduce such that they no longer require treatment with romiplostim during the month treatment period will continue with all required study procedures up to 12 months and will be monitored for ITP remission for at least 6 months.

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Volume 1, NumberJunepages Thrombocytopenia in Adults: Review Article. There are three main reasons of thrombocytopenia, a-Decreasing of making platelet b-Increasing of destruction platelet c-Changing of distribution platelet.

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Thrombocytopenia is a condition in which you have a low blood platelet count. Platelets thrombocytes are colorless blood cells that help blood clot. Platelets stop bleeding by clumping and forming plugs in blood vessel injuries.

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Idiopathic thrombocytopenia purpura ITP is a condition that causes low platelets. Platelets are small cells that circulate in the blood that are responsible for preventing bleeding and bruising. Patients with low platelets are at risk of bruising and rarely, serious bleeding.

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Dose adjustments were based on platelet counts. Patients could have doses of concurrent ITP medications adjusted during the first 12 weeks. Please see full Prescribing Information and Medication Guide.

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Immune thrombocytopenia ITP comprises a heterogeneous group of disorders characterized by autoimmune-mediated platelet destruction and impairment of platelet production. ITP is classified by duration of disease. Adult-onset ITP was once thought to be largely a disease of young women.

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Adult primary immune thrombocytopenia ITP is an autoimmune-mediated haemorrhagic disorder. Interleukin IL can directly affect cellular or humoural immunity by mediating the cellular cross-talk among T cells, B cells and dendritic cells. Several studies have focused on IL as an immunomodulatory cytokine that takes part in Th1 polarization in autoimmune diseases.

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Patient information: See related handout on low platelet countwritten by the authors of this article. It is often discovered incidentally when obtaining a complete blood count during an office visit. The etiology usually is not obvious, and additional investigation is required.

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Marlene Williams, M. Platelets, the smallest of our blood cells, can only be seen under a microscope. A blood vessel will send out a signal when it becomes damaged. To make contact with the broken blood vessel, platelets grow long tentacles and then resemble a spider or an octopus.

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